Drug interactions
Nelfinavir + Nifedipine
Severity: Moderate
Nelfinavir and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may raise nifedipine concentrations, causing hypotension, flushing and edema. Nifedipine has no meaningful effect on nelfinavir.
What this interaction means in plain words
Nelfinavir and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Nifedipine belongs to Cardiovascular.
Why it happens
Nelfinavir inhibits CYP3A4-mediated nifedipine metabolism.
What to do
Start nifedipine at a low dose and titrate with blood pressure monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Nifedipine?
MediHelp rates the interaction as moderate. Nelfinavir and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and may raise nifedipine concentrations, causing hypotension, flushing and edema. Nifedipine has no meaningful effect on nelfinavir.
How serious is the interaction between Nelfinavir and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nifedipine at a low dose and titrate with blood pressure monitoring.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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