Drug interactions
Nelfinavir + Pioglitazone
Severity: Minor
Nelfinavir and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may modestly raise pioglitazone concentrations through inhibition of its hepatic metabolism. This could increase dose-related effects such as fluid retention, edema and hypoglycemia, although the effect is expected to be small. Nelfinavir also causes metabolic disturbances that can affect glucose control.
What this interaction means in plain words
Nelfinavir and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nelfinavir belongs to Anti Virals; Pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 (and possibly CYP2C8) by nelfinavir reduces pioglitazone clearance.
What to do
Monitor blood glucose and for edema or weight gain when starting or stopping nelfinavir. Adjust the pioglitazone dose if glycemic control or fluid status changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nelfinavir and Pioglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Pioglitazone
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Pioglitazone?
MediHelp rates the interaction as minor. Nelfinavir and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir may modestly raise pioglitazone concentrations through inhibition of its hepatic metabolism. This could increase dose-related effects such as fluid retention, edema and hypoglycemia, although the effect is expected to be small. Nelfinavir also causes metabolic disturbances that can affect glucose control.
How serious is the interaction between Nelfinavir and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for edema or weight gain when starting or stopping nelfinavir. Adjust the pioglitazone dose if glycemic control or fluid status changes.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
