Drug interactions
Nelfinavir + Sacubitril-valsartan
Severity: Minor
Nelfinavir and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic uptake transporters such as OATP1B1, and inhibitors may raise valsartan exposure. Nelfinavir is a possible weak inhibitor, so any increase in effect is likely small. Hypotension and hyperkalemia could theoretically be enhanced.
What this interaction means in plain words
Nelfinavir and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nelfinavir belongs to Anti Virals; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan, reducing its hepatic clearance.
What to do
No dose adjustment is generally required; monitor blood pressure and renal function when starting or stopping nelfinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Nelfinavir and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic uptake transporters such as OATP1B1, and inhibitors may raise valsartan exposure. Nelfinavir is a possible weak inhibitor, so any increase in effect is likely small. Hypotension and hyperkalemia could theoretically be enhanced.
How serious is the interaction between Nelfinavir and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor blood pressure and renal function when starting or stopping nelfinavir.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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