Drug interactions
Nelfinavir + Sorafenib
Severity: Minor
Nelfinavir and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may modestly raise sorafenib levels. Studies with the strong CYP3A4 inhibitor ketoconazole showed no meaningful change in sorafenib exposure, so the effect is probably small.
What this interaction means in plain words
Nelfinavir and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nelfinavir belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
Nelfinavir inhibits CYP3A4-mediated sorafenib metabolism.
What to do
No routine dose change is needed. Monitor for sorafenib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Sorafenib?
MediHelp rates the interaction as minor. Nelfinavir and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir inhibits CYP3A4 and may modestly raise sorafenib levels. Studies with the strong CYP3A4 inhibitor ketoconazole showed no meaningful change in sorafenib exposure, so the effect is probably small.
How serious is the interaction between Nelfinavir and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sorafenib adverse effects.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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