Drug interactions
Nelfinavir + Valsartan
Severity: Minor
Nelfinavir and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic uptake transporters such as OATP1B1 and the efflux transporter MRP2. Inhibition by nelfinavir may raise valsartan exposure and could increase hypotension or renal effects. The clinical significance is not well characterized.
What this interaction means in plain words
Nelfinavir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nelfinavir belongs to Anti Virals; Valsartan belongs to Cardiovascular.
Why it happens
Possible inhibition of hepatic OATP1B1 uptake of valsartan, based largely on in vitro data.
What to do
Monitor blood pressure and renal function when starting nelfinavir in patients on valsartan, and reduce valsartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Valsartan?
MediHelp rates the interaction as minor. Nelfinavir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic uptake transporters such as OATP1B1 and the efflux transporter MRP2. Inhibition by nelfinavir may raise valsartan exposure and could increase hypotension or renal effects. The clinical significance is not well characterized.
How serious is the interaction between Nelfinavir and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when starting nelfinavir in patients on valsartan, and reduce valsartan dose if hypotension occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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