Drug interactions
Nelfinavir + Vincristine
Severity: Major
Nelfinavir and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can increase vincristine exposure. Protease inhibitors have been associated with severe vincristine neurotoxicity and ileus, so this combination can be harmful.
What this interaction means in plain words
Nelfinavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nelfinavir belongs to Anti Virals; Vincristine belongs to Oncology.
Why it happens
Inhibition of CYP3A4 (and possibly P-glycoprotein) by nelfinavir reduces vincristine clearance.
What to do
Avoid if possible by using an antiretroviral regimen without a CYP3A4 inhibitor during vincristine therapy. If unavoidable, monitor closely for neuropathy, constipation and ileus and reduce vincristine as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Vincristine?
MediHelp rates the interaction as major. Nelfinavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nelfinavir inhibits CYP3A4 and can increase vincristine exposure. Protease inhibitors have been associated with severe vincristine neurotoxicity and ileus, so this combination can be harmful.
How serious is the interaction between Nelfinavir and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible by using an antiretroviral regimen without a CYP3A4 inhibitor during vincristine therapy. If unavoidable, monitor closely for neuropathy, constipation and ileus and reduce vincristine as needed.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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