Drug interactions
Neomycin + Salsalate
Severity: Minor
Neomycin and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates may reduce aminoglycoside renal clearance, described mainly in preterm infants. Oral neomycin is poorly absorbed, so the effect is rarely significant.
What this interaction means in plain words
Neomycin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced renal prostaglandin-mediated perfusion lowers aminoglycoside clearance.
What to do
No routine action; monitor renal function in neonates or patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Neomycin with Salsalate?
MediHelp rates the interaction as minor. Neomycin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates may reduce aminoglycoside renal clearance, described mainly in preterm infants. Oral neomycin is poorly absorbed, so the effect is rarely significant.
How serious is the interaction between Neomycin and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; monitor renal function in neonates or patients with renal impairment.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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