Drug interactions
Neomycin + Tenofovir df
Severity: Moderate
Neomycin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can injure the kidney, and oral neomycin is absorbed to a small degree, which may be greater with damaged gut mucosa or renal impairment. Together with tenofovir's proximal tubular toxicity, this may add to the risk of renal impairment and aminoglycoside ototoxicity.
What this interaction means in plain words
Neomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxic effects on the renal tubule, with possible reduced renal clearance of tenofovir when renal function declines.
What to do
Monitor serum creatinine and electrolytes during combined use and keep neomycin courses short. Reduce or stop one agent if renal function worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Neomycin with Tenofovir df?
MediHelp rates the interaction as moderate. Neomycin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can injure the kidney, and oral neomycin is absorbed to a small degree, which may be greater with damaged gut mucosa or renal impairment. Together with tenofovir's proximal tubular toxicity, this may add to the risk of renal impairment and aminoglycoside ototoxicity.
How serious is the interaction between Neomycin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes during combined use and keep neomycin courses short. Reduce or stop one agent if renal function worsens.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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