Drug interactions
Neomycin + Typhoid vaccine live
Severity: Moderate
Neomycin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin acts in the gut and could reduce viability of the oral live attenuated typhoid vaccine, though Salmonella susceptibility to aminoglycosides in the gut is variable. The effect on vaccine response is uncertain.
What this interaction means in plain words
Neomycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity in the intestinal lumen may inhibit the live attenuated vaccine strain.
What to do
Complete neomycin therapy before giving oral typhoid vaccine, or use the inactivated injectable vaccine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Neomycin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Neomycin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin acts in the gut and could reduce viability of the oral live attenuated typhoid vaccine, though Salmonella susceptibility to aminoglycosides in the gut is variable. The effect on vaccine response is uncertain.
How serious is the interaction between Neomycin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete neomycin therapy before giving oral typhoid vaccine, or use the inactivated injectable vaccine.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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