Drug interactions
Neomycin po + Sulindac
Severity: Minor
Neomycin po and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic exposure is minimal in most patients. The reported effect of NSAIDs on aminoglycoside clearance is mainly in preterm infants, with limited relevance to oral neomycin in adults.
What this interaction means in plain words
Neomycin po and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-related reduction in renal clearance of aminoglycosides, relevant mainly with systemic absorption.
What to do
No specific action is needed in most patients; monitor renal function if the patient has renal impairment or gut inflammation with increased absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Neomycin po and Sulindac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Neomycin po with Sulindac?
MediHelp rates the interaction as minor. Neomycin po and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic exposure is minimal in most patients. The reported effect of NSAIDs on aminoglycoside clearance is mainly in preterm infants, with limited relevance to oral neomycin in adults.
How serious is the interaction between Neomycin po and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed in most patients; monitor renal function if the patient has renal impairment or gut inflammation with increased absorption.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
