Drug interactions
Neomycin po + Warfarin
Severity: Moderate
Neomycin po and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin may enhance warfarin's effect and raise the INR. It reduces vitamin K-producing gut bacteria and may reduce vitamin K absorption.
What this interaction means in plain words
Neomycin po and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Suppression of intestinal flora that produce vitamin K and possible reduced vitamin K absorption.
What to do
Monitor INR during neomycin therapy and adjust the warfarin dose if the INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Neomycin po with Warfarin?
MediHelp rates the interaction as moderate. Neomycin po and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin may enhance warfarin's effect and raise the INR. It reduces vitamin K-producing gut bacteria and may reduce vitamin K absorption.
How serious is the interaction between Neomycin po and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR during neomycin therapy and adjust the warfarin dose if the INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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