Drug interactions
Nettle + Tolbutamide
Severity: Minor
Nettle and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nettle has been reported to have blood glucose-lowering activity in some preparations. Taken with tolbutamide it could add to the glucose-lowering effect, although clinical evidence is sparse and the interaction is mostly theoretical.
What this interaction means in plain words
Nettle and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect; the mechanism is not well established.
What to do
Advise patients to report hypoglycemic symptoms and check capillary glucose more often when starting or stopping nettle products; reduce the tolbutamide dose if readings fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Nettle with Tolbutamide?
MediHelp rates the interaction as minor. Nettle and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nettle has been reported to have blood glucose-lowering activity in some preparations. Taken with tolbutamide it could add to the glucose-lowering effect, although clinical evidence is sparse and the interaction is mostly theoretical.
How serious is the interaction between Nettle and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report hypoglycemic symptoms and check capillary glucose more often when starting or stopping nettle products; reduce the tolbutamide dose if readings fall.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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