Drug interactions
Netupitant-palonosetron + Norgestrel
Severity: Minor
Netupitant-palonosetron and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant inhibits CYP3A4, which participates in progestin metabolism, so norgestrel exposure may rise somewhat. The increase is expected to be modest and is unlikely to reduce contraceptive efficacy, though progestogenic adverse effects may be more frequent.
What this interaction means in plain words
Netupitant-palonosetron and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Norgestrel belongs to Endocrine.
Why it happens
Netupitant inhibits CYP3A4, reducing norgestrel clearance.
What to do
No dose change is needed; advise patients to report unusual progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Netupitant-palonosetron with Norgestrel?
MediHelp rates the interaction as minor. Netupitant-palonosetron and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Netupitant inhibits CYP3A4, which participates in progestin metabolism, so norgestrel exposure may rise somewhat. The increase is expected to be modest and is unlikely to reduce contraceptive efficacy, though progestogenic adverse effects may be more frequent.
How serious is the interaction between Netupitant-palonosetron and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; advise patients to report unusual progestogenic adverse effects.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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