Drug interactions
Netupitant-palonosetron + Phenelzine
Severity: Major
Netupitant-palonosetron and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors raise serotonin availability, and adding a 5-HT3 antagonist increases the risk of serotonin syndrome, which can be severe and include hyperthermia and rigidity.
What this interaction means in plain words
Netupitant-palonosetron and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Phenelzine belongs to Central Nervous System.
Why it happens
Additive serotonergic effects with MAO inhibition.
What to do
Avoid if possible and choose a non-serotonergic antiemetic. If unavoidable, monitor closely for serotonin syndrome.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Netupitant-palonosetron with Phenelzine?
MediHelp rates the interaction as major. Netupitant-palonosetron and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MAO inhibitors raise serotonin availability, and adding a 5-HT3 antagonist increases the risk of serotonin syndrome, which can be severe and include hyperthermia and rigidity.
How serious is the interaction between Netupitant-palonosetron and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose a non-serotonergic antiemetic. If unavoidable, monitor closely for serotonin syndrome.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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