Drug interactions
Netupitant / palonosetron + Quinidine
Severity: Moderate
Netupitant / palonosetron and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine, a weak CYP3A4 inhibitor, may modestly raise netupitant levels. Additionally, netupitant is a moderate CYP3A4 inhibitor that could increase quinidine concentrations, and palonosetron can affect QT interval, so cardiac effects are relevant.
What this interaction means in plain words
Netupitant / palonosetron and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual CYP3A4 inhibition affects netupitant and quinidine clearance, with additive QT effects possible.
What to do
Monitor ECG and electrolytes when given for chemotherapy-induced nausea in patients on quinidine. Watch for quinidine toxicity and consider a quinidine dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Quinidine?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine, a weak CYP3A4 inhibitor, may modestly raise netupitant levels. Additionally, netupitant is a moderate CYP3A4 inhibitor that could increase quinidine concentrations, and palonosetron can affect QT interval, so cardiac effects are relevant.
How serious is the interaction between Netupitant / palonosetron and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes when given for chemotherapy-induced nausea in patients on quinidine. Watch for quinidine toxicity and consider a quinidine dose reduction.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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