Drug interactions
Netupitant-palonosetron + Trabectedin
Severity: Moderate
Netupitant-palonosetron and Trabectedin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant inhibits CYP3A4, which is the main pathway of trabectedin metabolism, so trabectedin exposure may increase. This raises the risk of hepatotoxicity, myelosuppression and rhabdomyolysis.
What this interaction means in plain words
Netupitant-palonosetron and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Trabectedin belongs to Oncology.
Why it happens
Netupitant inhibits CYP3A4, reducing trabectedin clearance.
What to do
Monitor liver enzymes, CK and blood counts closely. Where possible use an antiemetic that does not inhibit CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Netupitant-palonosetron and Trabectedin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Trabectedin
Frequently asked questions
Can I take Netupitant-palonosetron with Trabectedin?
MediHelp rates the interaction as moderate. Netupitant-palonosetron and Trabectedin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant inhibits CYP3A4, which is the main pathway of trabectedin metabolism, so trabectedin exposure may increase. This raises the risk of hepatotoxicity, myelosuppression and rhabdomyolysis.
How serious is the interaction between Netupitant-palonosetron and Trabectedin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, CK and blood counts closely. Where possible use an antiemetic that does not inhibit CYP3A4.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
