Drug interactions
Netupitant / palonosetron + Tranylcypromine
Severity: Moderate
Netupitant / palonosetron and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palonosetron is a 5-HT3 antagonist, and serotonin syndrome has been reported with this class when combined with serotonergic drugs. Netupitant is also a CYP3A4 inhibitor, and tranylcypromine increases serotonin availability, so serotonin toxicity is possible, though the risk is low.
What this interaction means in plain words
Netupitant / palonosetron and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects with MAO inhibition; the contribution of 5-HT3 antagonism is not well established.
What to do
Monitor for agitation, tremor, hyperthermia and clonus after administration. Stop the antiemetic and treat supportively if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Tranylcypromine?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palonosetron is a 5-HT3 antagonist, and serotonin syndrome has been reported with this class when combined with serotonergic drugs. Netupitant is also a CYP3A4 inhibitor, and tranylcypromine increases serotonin availability, so serotonin toxicity is possible, though the risk is low.
How serious is the interaction between Netupitant / palonosetron and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and clonus after administration. Stop the antiemetic and treat supportively if serotonin syndrome develops.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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