Drug interactions
Netupitant / palonosetron + Vardenafil
Severity: Moderate
Netupitant / palonosetron and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a moderate CYP3A4 inhibitor and can raise vardenafil concentrations. Palonosetron adds slight QT concern. This may increase hypotension and other adverse effects.
What this interaction means in plain words
Netupitant / palonosetron and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Netupitant inhibits CYP3A4-mediated metabolism of vardenafil.
What to do
Consider a reduced vardenafil dose and monitor blood pressure and ECG if there are other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Vardenafil?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant is a moderate CYP3A4 inhibitor and can raise vardenafil concentrations. Palonosetron adds slight QT concern. This may increase hypotension and other adverse effects.
How serious is the interaction between Netupitant / palonosetron and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a reduced vardenafil dose and monitor blood pressure and ECG if there are other QT risk factors.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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