Drug interactions
Nicardipine + Nitroglycerin rectal
Severity: Moderate
Nicardipine and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers combined with organic nitrates can produce additive vasodilation. Orthostatic hypotension, dizziness, and syncope have been reported, and reflex tachycardia may occur.
What this interaction means in plain words
Nicardipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasodilation through calcium channel blockade and nitric oxide-mediated smooth muscle relaxation.
What to do
Monitor blood pressure and orthostatic symptoms, particularly after dose changes. Advise patients to rise slowly and reduce a dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nicardipine and Nitroglycerin rectal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Nicardipine and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium channel blockers combined with organic nitrates can produce additive vasodilation. Orthostatic hypotension, dizziness, and syncope have been reported, and reflex tachycardia may occur.
How serious is the interaction between Nicardipine and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly after dose changes. Advise patients to rise slowly and reduce a dose if symptomatic hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
