Drug interactions
Nicardipine + Nitroglycerin sublingual
Severity: Moderate
Nicardipine and Nitroglycerin sublingual: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents vasodilate, and together they can cause pronounced hypotension, dizziness and syncope. Reflex tachycardia may also occur.
What this interaction means in plain words
Nicardipine and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from calcium channel blockade and nitric oxide-mediated smooth muscle relaxation.
What to do
Counsel patients to sit before taking sublingual nitroglycerin and monitor blood pressure and orthostatic symptoms. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Nitroglycerin sublingual?
MediHelp rates the interaction as moderate. Nicardipine and Nitroglycerin sublingual can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents vasodilate, and together they can cause pronounced hypotension, dizziness and syncope. Reflex tachycardia may also occur.
How serious is the interaction between Nicardipine and Nitroglycerin sublingual?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to sit before taking sublingual nitroglycerin and monitor blood pressure and orthostatic symptoms. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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