Drug interactions
Nicardipine + Olaparib
Severity: Moderate
Nicardipine and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is cleared by CYP3A4, and nicardipine may modestly raise its levels. Greater exposure could increase anemia, nausea and fatigue.
What this interaction means in plain words
Nicardipine and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Olaparib belongs to Oncology.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing olaparib metabolism.
What to do
Monitor blood counts and tolerability, reducing olaparib per labeling only if toxicity occurs. Dose reduction is mandated only with strong or moderate inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Nicardipine with Olaparib?
MediHelp rates the interaction as moderate. Nicardipine and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib is cleared by CYP3A4, and nicardipine may modestly raise its levels. Greater exposure could increase anemia, nausea and fatigue.
How serious is the interaction between Nicardipine and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tolerability, reducing olaparib per labeling only if toxicity occurs. Dose reduction is mandated only with strong or moderate inhibitors.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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