Drug interactions
Nicardipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Major
Nicardipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens strongly inhibit CYP3A4 and can substantially raise nicardipine exposure. This may cause hypotension, edema and tachycardia.
What this interaction means in plain words
Nicardipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 metabolism of nicardipine by ritonavir and paritaprevir.
What to do
Start with a reduced nicardipine dose and titrate by blood pressure and heart rate response, or choose an alternative antihypertensive.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as major. Nicardipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted regimens strongly inhibit CYP3A4 and can substantially raise nicardipine exposure. This may cause hypotension, edema and tachycardia.
How serious is the interaction between Nicardipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a reduced nicardipine dose and titrate by blood pressure and heart rate response, or choose an alternative antihypertensive.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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