Drug interactions
Nicardipine + Pentobarbital
Severity: Moderate
Nicardipine and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and can lower nicardipine concentrations. Blood pressure control may be reduced, particularly with repeated or chronic barbiturate use.
What this interaction means in plain words
Nicardipine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-induced CYP3A4 expression increases nicardipine metabolism.
What to do
Monitor blood pressure and titrate nicardipine upward if control is lost. Reassess the dose when the barbiturate is stopped, since levels will rise again.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Pentobarbital?
MediHelp rates the interaction as moderate. Nicardipine and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and can lower nicardipine concentrations. Blood pressure control may be reduced, particularly with repeated or chronic barbiturate use.
How serious is the interaction between Nicardipine and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nicardipine upward if control is lost. Reassess the dose when the barbiturate is stopped, since levels will rise again.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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