Drug interactions
Nicardipine + Pindolol
Severity: Moderate
Nicardipine and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a dihydropyridine calcium channel blocker with a beta-blocker produces additive blood pressure lowering. In susceptible patients it may cause excessive hypotension, bradycardia or worsening heart failure.
What this interaction means in plain words
Nicardipine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effects from vasodilation and beta-adrenergic blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug, with extra care in left ventricular dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Pindolol?
MediHelp rates the interaction as moderate. Nicardipine and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a dihydropyridine calcium channel blocker with a beta-blocker produces additive blood pressure lowering. In susceptible patients it may cause excessive hypotension, bradycardia or worsening heart failure.
How serious is the interaction between Nicardipine and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug, with extra care in left ventricular dysfunction.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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