Drug interactions
Nicardipine + Prazosin
Severity: Moderate
Nicardipine and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure and may cause additive hypotension. First-dose or dose-increase orthostatic hypotension and syncope are the main concerns.
What this interaction means in plain words
Nicardipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive vasodilation from calcium channel blockade and alpha-1 adrenergic blockade.
What to do
Start with low doses and titrate gradually, with blood pressure monitored including standing readings. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Nicardipine with Prazosin?
MediHelp rates the interaction as moderate. Nicardipine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure and may cause additive hypotension. First-dose or dose-increase orthostatic hypotension and syncope are the main concerns.
How serious is the interaction between Nicardipine and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate gradually, with blood pressure monitored including standing readings. Advise patients to rise slowly.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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