Drug interactions
Nicardipine + Propranolol
Severity: Moderate
Nicardipine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they produce additive blood pressure lowering, and nicardipine may raise propranolol concentrations. Hypotension and, less commonly, bradycardia or heart failure may occur, especially with impaired ventricular function.
What this interaction means in plain words
Nicardipine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive vasodilation and negative chronotropic effects, with reduced propranolol clearance through CYP inhibition or hemodynamic changes.
What to do
Monitor blood pressure, heart rate and signs of heart failure when starting or adjusting either drug. Reduce the propranolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nicardipine and Propranolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Propranolol?
MediHelp rates the interaction as moderate. Nicardipine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together they produce additive blood pressure lowering, and nicardipine may raise propranolol concentrations. Hypotension and, less commonly, bradycardia or heart failure may occur, especially with impaired ventricular function.
How serious is the interaction between Nicardipine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of heart failure when starting or adjusting either drug. Reduce the propranolol dose if bradycardia or hypotension develops.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
