Drug interactions
Nicardipine + Quinupristin / dalfopristin
Severity: Moderate
Nicardipine and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and can raise levels of CYP3A4 substrates such as nicardipine. This may cause hypotension, flushing, and edema.
What this interaction means in plain words
Nicardipine and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by quinupristin/dalfopristin reduces nicardipine metabolism.
What to do
Monitor blood pressure and heart rate during the antibiotic course. Lower the nicardipine dose if hypotension or vasodilatory effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Nicardipine and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and can raise levels of CYP3A4 substrates such as nicardipine. This may cause hypotension, flushing, and edema.
How serious is the interaction between Nicardipine and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during the antibiotic course. Lower the nicardipine dose if hypotension or vasodilatory effects appear.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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