Drug interactions
Nicardipine + Romidepsin
Severity: Moderate
Nicardipine and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit P-glycoprotein, and romidepsin is a P-glycoprotein and CYP3A4 substrate, so its exposure could rise. Clinical evidence is limited, but romidepsin toxicity such as cytopenias, nausea, and QT effects could be increased.
What this interaction means in plain words
Nicardipine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of P-glycoprotein and CYP3A4 by nicardipine reduces romidepsin clearance.
What to do
Monitor blood counts, electrolytes, and ECG during romidepsin therapy. Consider an alternative antihypertensive if romidepsin toxicity is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nicardipine and Romidepsin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Romidepsin?
MediHelp rates the interaction as moderate. Nicardipine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may inhibit P-glycoprotein, and romidepsin is a P-glycoprotein and CYP3A4 substrate, so its exposure could rise. Clinical evidence is limited, but romidepsin toxicity such as cytopenias, nausea, and QT effects could be increased.
How serious is the interaction between Nicardipine and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, electrolytes, and ECG during romidepsin therapy. Consider an alternative antihypertensive if romidepsin toxicity is troublesome.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
