Drug interactions
Nicardipine + Sodium nitroprusside
Severity: Moderate
Nicardipine and Sodium nitroprusside: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine adds to nitroprusside vasodilation and can lead to excessive hypotension. Reflex tachycardia may also occur.
What this interaction means in plain words
Nicardipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Sodium nitroprusside belongs to Cardiovascular.
Why it happens
Additive arterial vasodilation through calcium channel blockade and nitric oxide-mediated relaxation.
What to do
Monitor arterial blood pressure continuously and reduce the nitroprusside infusion rate as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sodium nitroprusside
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Sodium nitroprusside?
MediHelp rates the interaction as moderate. Nicardipine and Sodium nitroprusside can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine adds to nitroprusside vasodilation and can lead to excessive hypotension. Reflex tachycardia may also occur.
How serious is the interaction between Nicardipine and Sodium nitroprusside?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor arterial blood pressure continuously and reduce the nitroprusside infusion rate as needed.
What other medicines interact with Sodium nitroprusside?
MediHelp also lists interactions of Sodium nitroprusside with, for example, Avanafil, Nitric oxide, Sildenafil. The full list is on the Sodium nitroprusside page.
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