Drug interactions
Nicardipine + Tofacitinib
Severity: Minor
Nicardipine and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP3A4 only weakly to moderately, so any increase in tofacitinib exposure is likely small. A clinically important interaction is unlikely.
What this interaction means in plain words
Nicardipine and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nicardipine belongs to Cardiovascular; Tofacitinib belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 inhibition may slightly reduce tofacitinib clearance.
What to do
No dose adjustment is usually needed; monitor for tofacitinib adverse effects such as infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Tofacitinib?
MediHelp rates the interaction as minor. Nicardipine and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits CYP3A4 only weakly to moderately, so any increase in tofacitinib exposure is likely small. A clinically important interaction is unlikely.
How serious is the interaction between Nicardipine and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for tofacitinib adverse effects such as infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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