Drug interactions
Nicardipine + Umeclidinium bromide / vilanterol inhaled
Severity: Minor
Nicardipine and Umeclidinium bromide / vilanterol inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may slightly increase systemic vilanterol exposure through CYP3A4 inhibition. This could enhance beta-agonist effects such as tachycardia, tremor or palpitations, though the effect is expected to be small with weak inhibitors.
What this interaction means in plain words
Nicardipine and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing the metabolism of vilanterol.
What to do
No routine adjustment is needed; monitor heart rate and for beta-agonist adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as minor. Nicardipine and Umeclidinium bromide / vilanterol inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may slightly increase systemic vilanterol exposure through CYP3A4 inhibition. This could enhance beta-agonist effects such as tachycardia, tremor or palpitations, though the effect is expected to be small with weak inhibitors.
How serious is the interaction between Nicardipine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor heart rate and for beta-agonist adverse effects.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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