Drug interactions
Nicardipine + Vilanterol / fluticasone furoate inhaled
Severity: Minor
Nicardipine and Vilanterol / fluticasone furoate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both inhaled components are CYP3A4 substrates, and nicardipine may modestly increase their systemic exposure. This could add to beta-agonist cardiovascular effects or corticosteroid systemic effects, though the effect is expected to be small.
What this interaction means in plain words
Nicardipine and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nicardipine weakly inhibits CYP3A4, decreasing clearance of fluticasone furoate and vilanterol.
What to do
No dose change is usually needed; monitor heart rate and for signs of systemic corticosteroid effects with long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nicardipine and Vilanterol / fluticasone furoate inhaled, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as minor. Nicardipine and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both inhaled components are CYP3A4 substrates, and nicardipine may modestly increase their systemic exposure. This could add to beta-agonist cardiovascular effects or corticosteroid systemic effects, though the effect is expected to be small.
How serious is the interaction between Nicardipine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor heart rate and for signs of systemic corticosteroid effects with long-term use.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
