Drug interactions
Nicardipine + Vorapaxar
Severity: Moderate
Nicardipine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is metabolized by CYP3A4, and nicardipine may modestly raise its levels. Increased vorapaxar exposure raises bleeding risk, though a weak or moderate inhibitor is not contraindicated by labeling.
What this interaction means in plain words
Nicardipine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nicardipine inhibits CYP3A4, reducing vorapaxar metabolism.
What to do
Monitor for signs of bleeding and reassess the need for combined therapy. Avoid if the patient has other bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Vorapaxar?
MediHelp rates the interaction as moderate. Nicardipine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is metabolized by CYP3A4, and nicardipine may modestly raise its levels. Increased vorapaxar exposure raises bleeding risk, though a weak or moderate inhibitor is not contraindicated by labeling.
How serious is the interaction between Nicardipine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and reassess the need for combined therapy. Avoid if the patient has other bleeding risk factors.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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