Drug interactions
Nicardipine + Xipamide
Severity: Moderate
Nicardipine and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic and adds to the blood pressure lowering of nicardipine. This is often used therapeutically but can cause hypotension, dizziness and volume depletion.
What this interaction means in plain words
Nicardipine and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: diuresis and volume reduction plus vasodilation.
What to do
Monitor blood pressure, especially at initiation and after dose changes, and check electrolytes and renal function. Lower the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Xipamide?
MediHelp rates the interaction as moderate. Nicardipine and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic and adds to the blood pressure lowering of nicardipine. This is often used therapeutically but can cause hypotension, dizziness and volume depletion.
How serious is the interaction between Nicardipine and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially at initiation and after dose changes, and check electrolytes and renal function. Lower the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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