Drug interactions
Nifedipine + Nilotinib
Severity: Moderate
Nifedipine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may raise nifedipine levels, causing hypotension and edema. Nilotinib also prolongs the QT interval, but nifedipine has little effect on nilotinib exposure.
What this interaction means in plain words
Nifedipine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Nilotinib inhibits CYP3A4, which may reduce nifedipine metabolism.
What to do
Monitor blood pressure and reduce the nifedipine dose if hypotension occurs. Continue standard ECG and electrolyte monitoring for nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nifedipine with Nilotinib?
MediHelp rates the interaction as moderate. Nifedipine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may raise nifedipine levels, causing hypotension and edema. Nilotinib also prolongs the QT interval, but nifedipine has little effect on nilotinib exposure.
How serious is the interaction between Nifedipine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and reduce the nifedipine dose if hypotension occurs. Continue standard ECG and electrolyte monitoring for nilotinib.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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