Drug interactions
Nifedipine + Pazopanib
Severity: Minor
Nifedipine and Pazopanib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak CYP3A4 inhibitor and a substrate. Its effect on pazopanib exposure is expected to be small, unlike strong inhibitors. Both drugs can raise blood pressure or cause edema effects, so overlapping toxicity monitoring is sensible.
What this interaction means in plain words
Nifedipine and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Pazopanib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated pazopanib metabolism by nifedipine.
What to do
No pazopanib dose reduction is needed, since that applies only to strong CYP3A4 inhibitors. Monitor blood pressure and liver tests as routinely recommended for pazopanib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Nifedipine with Pazopanib?
MediHelp rates the interaction as minor. Nifedipine and Pazopanib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a weak CYP3A4 inhibitor and a substrate. Its effect on pazopanib exposure is expected to be small, unlike strong inhibitors. Both drugs can raise blood pressure or cause edema effects, so overlapping toxicity monitoring is sensible.
How serious is the interaction between Nifedipine and Pazopanib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No pazopanib dose reduction is needed, since that applies only to strong CYP3A4 inhibitors. Monitor blood pressure and liver tests as routinely recommended for pazopanib.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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