Drug interactions
Nifedipine + Quinine
Severity: Minor
Nifedipine and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine may modestly raise nifedipine exposure through CYP3A4 effects, and reports suggest quinine can alter nifedipine levels. This could produce more hypotension, flushing or edema.
What this interaction means in plain words
Nifedipine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Competition for CYP3A4 metabolism; nifedipine is not a meaningful inhibitor of quinine clearance.
What to do
Monitor blood pressure and heart rate when quinine is started, and reduce the nifedipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Nifedipine and Quinine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Quinine?
MediHelp rates the interaction as minor. Nifedipine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinine may modestly raise nifedipine exposure through CYP3A4 effects, and reports suggest quinine can alter nifedipine levels. This could produce more hypotension, flushing or edema.
How serious is the interaction between Nifedipine and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when quinine is started, and reduce the nifedipine dose if hypotension occurs.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
