Drug interactions
Nifedipine + Rifabutin
Severity: Moderate
Nifedipine and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can markedly lower nifedipine exposure, with risk of inadequate antihypertensive or antianginal effect.
What this interaction means in plain words
Nifedipine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induction of CYP3A4 increases presystemic and hepatic metabolism of nifedipine.
What to do
Monitor blood pressure and anginal symptoms, and increase the nifedipine dose or choose a different agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Nifedipine with Rifabutin?
MediHelp rates the interaction as moderate. Nifedipine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and can markedly lower nifedipine exposure, with risk of inadequate antihypertensive or antianginal effect.
How serious is the interaction between Nifedipine and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms, and increase the nifedipine dose or choose a different agent if needed.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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