Drug interactions
Nifedipine + Rufinamide
Severity: Minor
Nifedipine and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and may modestly lower exposure to nifedipine. Blood pressure or angina control could be slightly reduced.
What this interaction means in plain words
Nifedipine and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increasing nifedipine metabolism.
What to do
Monitor blood pressure or angina control after starting or stopping rufinamide, and increase the nifedipine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Nifedipine with Rufinamide?
MediHelp rates the interaction as minor. Nifedipine and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and may modestly lower exposure to nifedipine. Blood pressure or angina control could be slightly reduced.
How serious is the interaction between Nifedipine and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure or angina control after starting or stopping rufinamide, and increase the nifedipine dose if needed.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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