Drug interactions
Nifedipine + Tadalafil
Severity: Moderate
Nifedipine and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and the combination can produce additive hypotension with dizziness or syncope. Nifedipine is a CYP3A4 substrate with little inhibitory effect, so a pharmacokinetic rise in tadalafil is not expected to be important.
What this interaction means in plain words
Nifedipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and calcium channel blockade.
What to do
Monitor blood pressure when tadalafil is started and use the lowest effective dose. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Tadalafil?
MediHelp rates the interaction as moderate. Nifedipine and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and the combination can produce additive hypotension with dizziness or syncope. Nifedipine is a CYP3A4 substrate with little inhibitory effect, so a pharmacokinetic rise in tadalafil is not expected to be important.
How serious is the interaction between Nifedipine and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when tadalafil is started and use the lowest effective dose. Counsel patients to rise slowly.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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