Drug interactions
Nifedipine + Terazosin
Severity: Moderate
Nifedipine and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-blocker with a dihydropyridine calcium channel blocker can cause additive blood pressure reduction. This may lead to symptomatic hypotension, dizziness and syncope, particularly on initiation.
What this interaction means in plain words
Nifedipine and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive vasodilation through alpha-1 receptor blockade and calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Titrate doses gradually and advise slow positional changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Terazosin?
MediHelp rates the interaction as moderate. Nifedipine and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-blocker with a dihydropyridine calcium channel blocker can cause additive blood pressure reduction. This may lead to symptomatic hypotension, dizziness and syncope, particularly on initiation.
How serious is the interaction between Nifedipine and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Titrate doses gradually and advise slow positional changes.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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