Drug interactions
Nifedipine + Timolol
Severity: Minor
Nifedipine and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This combination is widely used and gives additive blood pressure lowering. Beta-blockade offsets nifedipine-related reflex tachycardia, but excessive hypotension or heart failure exacerbation may occur in vulnerable patients.
What this interaction means in plain words
Nifedipine and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of beta-blockade and dihydropyridine vasodilation.
What to do
Monitor blood pressure and for signs of heart failure when starting or titrating. Reduce doses if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Timolol?
MediHelp rates the interaction as minor. Nifedipine and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This combination is widely used and gives additive blood pressure lowering. Beta-blockade offsets nifedipine-related reflex tachycardia, but excessive hypotension or heart failure exacerbation may occur in vulnerable patients.
How serious is the interaction between Nifedipine and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for signs of heart failure when starting or titrating. Reduce doses if symptomatic hypotension develops.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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