Drug interactions
Nifedipine + Tolterodine
Severity: Minor
Nifedipine and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a weak CYP3A4 substrate and a possible weak inhibitor, and any rise in tolterodine exposure is expected to be small. Tolterodine is mainly cleared by CYP2D6, so the effect is unlikely to matter clinically in most patients.
What this interaction means in plain words
Nifedipine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Tolterodine belongs to Genitourinary.
Why it happens
Possible weak inhibition of CYP3A4-mediated tolterodine metabolism, which is a secondary pathway.
What to do
No routine dose change is needed. Watch for anticholinergic effects such as dry mouth or constipation if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Nifedipine
Frequently asked questions
Can I take Nifedipine with Tolterodine?
MediHelp rates the interaction as minor. Nifedipine and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a weak CYP3A4 substrate and a possible weak inhibitor, and any rise in tolterodine exposure is expected to be small. Tolterodine is mainly cleared by CYP2D6, so the effect is unlikely to matter clinically in most patients.
How serious is the interaction between Nifedipine and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Watch for anticholinergic effects such as dry mouth or constipation if symptoms emerge.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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