Drug interactions
Nifedipine + Tolvaptan
Severity: Minor
Nifedipine and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is a CYP3A4 substrate, but nifedipine is only a weak inhibitor, so any rise in tolvaptan exposure is expected to be modest. Increased tolvaptan effect could cause excess aquaresis, thirst or rapid sodium rise.
What this interaction means in plain words
Nifedipine and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nifedipine belongs to Cardiovascular; Tolvaptan belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition by nifedipine may slightly reduce tolvaptan clearance.
What to do
No dose change is generally needed. Monitor serum sodium and fluid status after starting tolvaptan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Nifedipine with Tolvaptan?
MediHelp rates the interaction as minor. Nifedipine and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan is a CYP3A4 substrate, but nifedipine is only a weak inhibitor, so any rise in tolvaptan exposure is expected to be modest. Increased tolvaptan effect could cause excess aquaresis, thirst or rapid sodium rise.
How serious is the interaction between Nifedipine and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor serum sodium and fluid status after starting tolvaptan.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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