Drug interactions
Nifedipine + Vincristine
Severity: Moderate
Nifedipine and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a CYP3A4 and P-glycoprotein substrate, and nifedipine may modestly inhibit both. This could increase vincristine neurotoxicity, although clinical data are limited.
What this interaction means in plain words
Nifedipine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nifedipine belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Possible P-glycoprotein and weak CYP3A4 inhibition by nifedipine reducing vincristine clearance.
What to do
Monitor for peripheral neuropathy, constipation and ileus during treatment. Consider an alternative antihypertensive if neurotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Nifedipine with Vincristine?
MediHelp rates the interaction as moderate. Nifedipine and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is a CYP3A4 and P-glycoprotein substrate, and nifedipine may modestly inhibit both. This could increase vincristine neurotoxicity, although clinical data are limited.
How serious is the interaction between Nifedipine and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and ileus during treatment. Consider an alternative antihypertensive if neurotoxicity develops.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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