Drug interactions
Nilotinib + Pantoprazole
Severity: Moderate
Nilotinib and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression with a proton pump inhibitor can lower nilotinib absorption because the drug dissolves poorly at higher gastric pH. This may reduce exposure and lead to loss of antileukemic efficacy. Separating the doses does not reliably prevent the effect because of the long duration of acid suppression.
What this interaction means in plain words
Nilotinib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nilotinib belongs to Oncology; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH reduces the pH-dependent solubility and absorption of nilotinib.
What to do
Avoid long-term PPI use where possible; if acid suppression is required, use a short-acting antacid or an H2 blocker timed away from nilotinib. Monitor molecular response to treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Nilotinib with Pantoprazole?
MediHelp rates the interaction as moderate. Nilotinib and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acid suppression with a proton pump inhibitor can lower nilotinib absorption because the drug dissolves poorly at higher gastric pH. This may reduce exposure and lead to loss of antileukemic efficacy. Separating the doses does not reliably prevent the effect because of the long duration of acid suppression.
How serious is the interaction between Nilotinib and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term PPI use where possible; if acid suppression is required, use a short-acting antacid or an H2 blocker timed away from nilotinib. Monitor molecular response to treatment.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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