Drug interactions
Nilotinib + Pioglitazone
Severity: Minor
Nilotinib and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib may inhibit CYP3A4 and slightly raise pioglitazone levels. Because pioglitazone relies mostly on CYP2C8, the clinical effect is likely small.
What this interaction means in plain words
Nilotinib and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Pioglitazone belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated pioglitazone metabolism.
What to do
No routine adjustment is needed. Monitor for edema and hypoglycemia if pioglitazone effects seem increased.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Pioglitazone?
MediHelp rates the interaction as minor. Nilotinib and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib may inhibit CYP3A4 and slightly raise pioglitazone levels. Because pioglitazone relies mostly on CYP2C8, the clinical effect is likely small.
How serious is the interaction between Nilotinib and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for edema and hypoglycemia if pioglitazone effects seem increased.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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