Drug interactions
Nilotinib + Prednisolone
Severity: Minor
Nilotinib and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and may modestly increase prednisolone exposure, though the clinical effect is likely small. Nilotinib also prolongs the QT interval, and corticosteroid-induced hypokalemia could add to that risk.
What this interaction means in plain words
Nilotinib and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nilotinib belongs to Oncology; Prednisolone belongs to Endocrine.
Why it happens
Nilotinib inhibits P-glycoprotein efflux, potentially reducing prednisolone clearance.
What to do
Monitor potassium and magnesium and obtain periodic ECGs as part of nilotinib therapy; watch for corticosteroid adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Prednisolone?
MediHelp rates the interaction as minor. Nilotinib and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits P-glycoprotein and may modestly increase prednisolone exposure, though the clinical effect is likely small. Nilotinib also prolongs the QT interval, and corticosteroid-induced hypokalemia could add to that risk.
How serious is the interaction between Nilotinib and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium and obtain periodic ECGs as part of nilotinib therapy; watch for corticosteroid adverse effects.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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