Drug interactions
Nilotinib + Selpercatinib
Severity: Major
Nilotinib and Selpercatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents prolong the QT interval, so combined use raises the risk of torsades de pointes. Selpercatinib is also a weak CYP3A4 inhibitor, which may modestly increase nilotinib levels.
What this interaction means in plain words
Nilotinib and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by selpercatinib.
What to do
Avoid the combination where possible. If used together, monitor ECG and electrolytes at baseline and regularly, and reduce or interrupt a drug if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Nilotinib with Selpercatinib?
MediHelp rates the interaction as major. Nilotinib and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents prolong the QT interval, so combined use raises the risk of torsades de pointes. Selpercatinib is also a weak CYP3A4 inhibitor, which may modestly increase nilotinib levels.
How serious is the interaction between Nilotinib and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used together, monitor ECG and electrolytes at baseline and regularly, and reduce or interrupt a drug if the QTc becomes markedly prolonged.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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