Drug interactions
Nilotinib + Sorafenib
Severity: Major
Nilotinib and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the chance of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances.
What this interaction means in plain words
Nilotinib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Obtain a baseline ECG and monitor QTc periodically, and keep potassium and magnesium normal. Avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Nilotinib with Sorafenib?
MediHelp rates the interaction as major. Nilotinib and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the chance of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances.
How serious is the interaction between Nilotinib and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically, and keep potassium and magnesium normal. Avoid additional QT-prolonging drugs.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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